Many São Paulo itineraries, especially in the center, can be filled with discoveries. Each São Paulo itinerary is an adventure in its own right. The key is to avoid slum areas, which are almost inevitable in such a huge city. São Paulo walking routes should definitely include Paulista Avenue and the central Republican Square.
Plan every São Paulo walking itinerary in advance, buy a map of the city or load it onto your smartphone. And be sure to include at least some of São Paulo's museums on your walking itinerary. If you're traveling on your own, take the subway or surface buses, which are dense and convenient.