You may need some vaccinations before traveling to São Paulo. Before traveling to any city in Brazil, not just São Paulo, find out if you need immunizations. Hepatitis A and B vaccinations are common. You may also need a vaccine against yellow fever, which has foci in some countries, such as Panama, Ecuador, Peru, and Colombia.
In such a case, you will need to show a certificate confirming that you have been immunized. When finding out what immunizations are required in São Paulo, many people ask about malaria. Today, a malaria vaccine is being developed, but there is no vaccine as such. The only medication available to protect against malaria are pills, which should be taken several weeks before traveling to areas with a high risk of malaria.