It's advisable to consider getting vaccinated against yellow fever before traveling to Samana. This is likely the only significant infectious disease you might encounter there. However, it's also crucial to exercise caution with water; avoid drinking tap water or ordering iced drinks.
Many travelers wonder if they need malaria vaccinations for Samana. While malaria is prevalent in the Dominican Republic, getting a specific vaccination for a trip to Samana is not necessary. Mosquitoes are relatively scarce in this area, and using regular insect repellent should suffice to protect you from infection.
There are no other diseases on the list of health concerns that require immunization for a trip to Samana.