Experineced tourists often recommend starting their journey by taking bus #78 to Heraklion bus station, which is just a 15-20 minute ride and costs a little over 1 EUR. Once in Heraklion, you can catch a direct bus to Agios Nikolaos, with schedules available on this website. Travel times vary between 1 hour (for express buses) to 1 hour and 40 minutes (for shuttle buses), with fares around 7 EUR.
Alternatively, you have the option to use the services of taxi drivers, providing a convenient and speedy way to reach Agios Nikolaos. Taxi services are available year-round, 24/7, although fares at night are typically double the daytime rates.
For those who prefer independence, renting a car at the airport is also an option.